Standard Practice for Evaluating Acute Systemic Toxicity of Material Extracts by Systemic Injection in the Mouse

Importancia y uso:

4.1 This practice is intended to help assess the biocompatibility of materials used in medical devices. It is an acute toxicological test designed to detect the presence of injurious leachable substances.

4.2 This practice may not be appropriate for all types of implant applications. The user is cautioned to consider the appropriateness of the method in view of the materials being tested, their potential applications, and the recommendations contained in Practice F748.

4.3 The only limitation applicable is the extract preparation. Refer to Section 4.3 of Practice F619 for a description of this limitation.

Subcomité:

F04.16

Referida por:

F2148-25, E3219-25, F0748-25

Volúmen:

13.01

Número ICS:

11.220 (Veterinary medicine)

Palabras clave:

acute toxicity tests; biocompatibility; intravenous injection; intraperitoneal injections; mouse/mice; test animals;