Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation

Importancia y uso:

4.1 Materials that are to be in contact with the skin should not cause irritation to the skin. Since it is probably the substances leached from a material that cause the irritation, this practice provides for direct material-skin contact testing or for skin exposure to the liquid extract of the test material. The rationale for this rabbit test is that it is a comparatively quick and sensitive method which, through use over the years, has become a generally accepted method. Additionally, the albino rabbit allows for easy visualization of erythema and edema, which are the cardinal signs of skin irritation.

Subcomité:

F04.16

Referida por:

F2808-23, F0748-25, E3219-25

Volúmen:

13.01

Número ICS:

11.100.99 (Other standards related to laboratory medicine)

Palabras clave:

acute toxicity tests; biocompatibility; rabbits; skin irritation; test animals;